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Sarcoma Treatment Overview

As the only National Cancer Institute-Designated Comprehensive Cancer Center in Georgia, Winship is a leader in the treatments for sarcoma, conducting innovative research and clinical trials that are transforming how these cancers are identified, treated, and survived.

The radiation oncologists at Emory Proton Therapy Center work with the multidisciplinary Sarcoma cancer team at Winship, which includes experts in sarcoma surgical oncology, orthopedicopaedic oncology, thoracic surgery, sarcoma medical oncology, radiology, sarcoma pathology, supportive oncology, dieticians, social workers, physical therapy, and cancer rehabilitation. Your radiation oncologist will work closely with these other specialists to customize your sarcoma treatment plan and coordinate your care. We can also partner and coordinate with a patient’s existing care team, whether they are across town or around the world.

Proton Therapy for Sarcoma

A sarcoma diagnosis can be one of the biggest challenges you and your family will ever face. Our team is dedicated to helping you meet that challenge through compassionate care using the most advanced treatments for sarcoma available. Proton therapy may be a more precise radiation option for treatment of your sarcoma to help protect the function of important nearby organs, as well as reducing the risk of developing a future cancer. Our cancer specialists will work with you to develop a personalized treatment plan which aims for fewer side effects and improved quality of life.

What We Treat

  • Retroperitoneal sarcomas
  • Abdominal sarcomas
  • Pelvic sarcomas
  • Bone sarcomas
  • Chordomas
  • Chondrosarcoma
  • Ewing’s sarcoma
  • Rhabdomyosarcoma
  • Liposarcoma
  • Leiomyosarcoma
  • Osteosarcoma
  • Desmoid tumors
  • Sarcoma metastases (lymph nodes, lung, liver, or adrenal)
  • Re-irradiation

Benefits of Proton Therapy

Sarcomas may occur anywhere in the body. Potential benefits of proton therapy depend on the type of sarcoma and location in the body. Click below to see the benefits for proton therapy for each body site.

Benefits for Head & Neck Sarcomas

  • Reduced risk of painful sores in the mouth (mucositis) during treatment.
  • Reduced risk of dental decay after radiation.
  • Reduced risk of problems swallowing (dysphagia or aspiration) during or after therapy.
  • Reduced risk of hoarseness during treatment.
  • Reduced risk of dry mouth (xerostomia) after radiation.
  • Reduced risk of hearing loss after radiation. This is relevant for tumors near the cochlea, such as those in the nasopharynx, paranasal sinuses, or skull base.
  • Reduced risk of hormone imbalances (endocrine dysfunction) which can particularly affect growth and development in children and young adults. This is relevant for tumors near the pituitary and hypothalamus, such as those in the nasopharynx, paranasal sinuses, or skull base.
  • Reduced radiation to the bone marrow and circulating lymphocytes, which may help support the function of the immune system in taking on cancer.
  • Reduced risk of developing a future second tumor or cancer, which is most relevant in younger patients, those with a good prognosis and a long life expectancy, and those patients who may have genetic conditions putting them at higher risk for developing other cancers.

Benefits for Chest Sarcomas

  • Reduced risk of inflammation of the heart (pericarditis) and future heart problems like hardening of the arteries (atherosclerosis), stiffening of the heart muscle (fibrosis, cardiomyopathy), and heart attacks.
  • Reduced risk of inflammation of the lungs (radiation pneumonitis) and problems with lung function (lung fibrosis).
  • Reduced risk of difficulty or pain with swallowing (dysphagia or odynophagia) or chronic narrowing of the esophagus (stricture).
  • Reduced radiation to the bone marrow and circulating lymphocytes, which may help support the function of the immune system in taking on fighting cancer.
  • Reduced risk of low blood counts (anemia, neutropenia) which may support the body’s tolerance of chemotherapy.
  • Reduced risk of developing a future second tumor or cancer, which is most relevant in younger patients, those with a good prognosis and a long life expectancy, and those patients who may have genetic conditions putting them at higher risk for developing other cancers.

Benefits for Retroperitoneal, Abdominal or Pelvic Sarcomas

  • Reduced risk of inflammation of the heart (pericarditis) and future heart problems like hardening of the arteries (atherosclerosis), stiffening of the heart muscle (fibrosis, cardiomyopathy), and heart attacks.
  • Reduced risk of new or worsening problems with liver function (radiation induced liver dysfunction). This is relevant for patients with large liver tumors and/or small remaining size of normal liver, for those with poor liver function (liver cirrhosis), or those who have had prior radiation treatments including prior liver radioembolization.
  • Reduced risk of nausea and diarrhea.
  • Reduced risk of new or worsening kidney function.
  • Reduced risk of frequent urination or stinging or burning with urination during treatment, or of chronic urinary problems after treatment.
  • Reduced risk of diarrhea and rectal soreness (proctitis) during treatment and of chronic rectal problems after treatments such as rectal bleeding or ulceration.
  • Reduced radiation to the bone marrow, spleen, and circulating lymphocytes, which may help support the function of the immune system in fighting cancer.
  • Reduced risk of low blood counts (anemia, neutropenia) which may support the body’s tolerance of chemotherapy.
  • Reduced risk of developing a future second tumor or cancer, which is most relevant in younger patients, those with a good prognosis and a long life expectancy, and those patients who may have genetic conditions putting them at higher risk for developing other cancers.

Benefits for Skull Base or Spine Sarcomas

  • Improved ability to treat radiation- resistant sarcomas near the brainstem or spinal cord with a high dose of radiation necessary for these tumors.
  • Reduced risk of inflammation of the heart (pericarditis) and future heart problems like hardening of the arteries (atherosclerosis), stiffening of the heart muscle (fibrosis, cardiomyopathy), and heart attacks. This is relevant for tumors near the heart, for example in the thoracic spine.
  • Reduced risk of inflammation of the lungs (radiation pneumonitis) and lung function (lung fibrosis). This is relevant for tumors near the lungs, for example in the thoracic spine.
  • Reduced risk of nausea and diarrhea. This is relevant for tumors near the bowels, for example in the lumbar or sacral spine.
  • Reduced radiation to the bone marrow and circulating lymphocytes, which may help support the function of the immune system in taking on fighting cancer.
  • Reduced risk of low blood counts (anemia, neutropenia) which may support the body’s tolerance of chemotherapy.
  • Reduced risk of developing a future second tumor or cancer, which is most relevant in younger patients, those with a good prognosis and a long life expectancy, and those patients who may have genetic conditions putting them at higher risk for developing other cancers.

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What To Expect From Proton Therapy

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The first step in your care is a consultation. During consultation, we review your medical history, perform a physical exam, decide if any additional tests are needed, discuss all radiation options that may be appropriate for your treatment plancare, make recommendations, and answer questions.

To plan your treatment, you will undergo a “simulation” or planning session. During this visit our radiation therapists will help position you the way you will be treated each day. A CT scan will be done to create a picture of you in the treatment position to design your radiation plan. Some patients also undergo an MRI during this visit to help identify the target for treatment. It normally takes 10 days for the team to design the proton treatment plan and perform the quality assurance checks before treatment begins.

Depending on the type of tumor and stage, proton therapy may be delivered over one to three weeks, six weeks, or eight weeks of therapy. Typically, radiation is given once daily during the weekdays, Monday through Friday. For those receiving five treatments or fewer, proton therapy may be delivered every other day. While some situations are treated with radiation alone, proton therapy is often integrated with surgery, chemotherapy, immunotherapy, or other cancer treatments as part of a comprehensive plan of care.

Like other types of radiation, proton therapy treatments are invisible and painless. Most sarcoma tumor treatments average 30 minutes each day in the treatment room. If your tumor is located in the abdomen, it may move significantly while breathing. During your radiation planning process, your team will identify the most appropriate methods to manage tumor motion, if necessary.

Patients are seen by the radiation oncology physician team weekly during treatment to monitor progress, answer questions, address concerns, and manage any side effects from treatment. Your radiation oncologist will discuss a plan to assess response to treatment and for long-term follow-up after therapy.

Studies on Proton Therapy in Sarcoma

Our team has identified these studies as examples of the clinical benefits of proton therapy in sarcoma.

Patient Stories