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Lymphoma Treatment Overview

As the only National Cancer Institute-designated Comprehensive Cancer Center in Georgia, Winship is a at the forefront in lymphoma cancer treatments, conducting innovative research and clinical trials that are transforming how these cancers are identified, treated, and survived.

The radiation oncologists at Emory Proton Therapy Center work with the multidisciplinary Lymphoma radiation therapy  team at Winship, which includes experts in hematology, transplant, radiology, pathology, supportive oncology, speech- language pathology, dieticians, social workers, physical therapy, and cancer rehabilitation. Your lymphoma radiation therapy oncologist will work closely with these other specialists to customize your treatment plan and coordinate your care.  We can also partner with a patient’s existing care team, whether they are across town or around the world.

Proton Therapy for Lymphoma

A lymphoma diagnosis can be one of the biggest challenges you and your family will ever face. Our team is dedicated to helping you meet that challenge through supportive care using the most advanced lymphoma treatment options available. Proton therapy may be a more precise radiation option for treatment of your lymphoma to help protect the function of important nearby organs like the heart and lungs, as well as reducing the risk of developing a future cancer.

Our cancer specialists will work with you to develop a personalized lymphoma cancer treatment plan which aims for fewer side effects and improved quality of life.

What We Treat

  • Hodgkin’s lymphoma
  • Non-Hodgkin’s lymphoma
  • Diffuse large B-cell lymphoma
  • Anaplastic large-cell lymphoma
  • Burkitt lymphoma
  • Mantle cell lymphoma
  • Marginal zone B-cell lymphoma
  • MALT lymphoma
  • Follicular lymphoma
  • Natural killer (NK) cell lymphoma

Benefits of Proton Therapy

Lymphomas may occur anywhere in the body. Potential benefits of proton therapy depend on the type of lymphoma and location in the body. Click below to see the benefits for proton therapy for each body site.

Benefits for Head & Neck Lymphomas

  • Reduced risk of painful sores in the mouth (mucositis) during treatment
  • Reduced risk of dry mouth (xerostomia) after radiation.
  • Reduced risk of dental decay after radiation.
  • Reduced risk of problems swallowing (dysphagia or aspiration) during or after therapy.
  • Reduced risk of hoarseness during treatment and problems swallowing (dysphagia or aspiration) after therapy.
  • Reduced risk of hearing loss after radiation. This is relevant for tumors near the cochlea, such as those in the nasopharynx, paranasal sinuses, or skull base.
  • Reduced risk of hormone imbalances (endocrine dysfunction) which can particularly affect growth and development in children and young adults. This is relevant for tumors near the pituitary and hypothalamus, such as those in the nasopharynx, paranasal sinuses, or skull base.
  • Reduced radiation to the bone marrow and circulating lymphocytes, which may help support the function of the immune system in taking on cancer.
  • Reduced risk of developing a future second tumor or cancer, which is most relevant in younger patients, those with a good prognosis and a long life expectancy, and those patients who may have genetic conditions putting them at higher risk for developing other cancers.

Benefits for Thoracic Lymphomas

  • Reduced risk of inflammation of the heart (pericarditis) and future heart problems like hardening of the arteries (atherosclerosis), stiffening of the heart muscle (fibrosis, cardiomyopathy), and heart attacks.
  • Reduced risk of inflammation of the lungs (radiation pneumonitis) and problems with lung function (lung fibrosis).
  • Reduced risk of difficulty or pain with swallowing (dysphagia or odynophagia) or chronic narrowing of the esophagus (stricture).
  • Reduced radiation to the bone marrow and circulating lymphocytes, which may help support the function of the immune system in taking on cancer.
  • Reduced the risk of low blood counts (anemia, neutropenia) which may support the body’s tolerance of chemotherapy.
  • Reduced risk of developing a future second tumor or cancer, which is most relevant in younger patients, those with a good prognosis and a long life expectancy, and those patients who may have genetic conditions putting them at higher risk for developing other cancers.

Benefits for Pelvic Lymphomas

  • Reduced risk of inflammation of the heart (pericarditis) and future heart problems like hardening of the arteries (atherosclerosis), stiffening of the heart muscle (fibrosis, cardiomyopathy), and heart attacks.
  • Reduced risk of new or worsening problems with liver function (radiation- induced liver dysfunction). This is relevant for patients with large liver tumors and/or small remaining size of normal liver, for those with poor liver function (liver cirrhosis), or who have had prior radiation treatments including prior liver radioembolization.
  • Reduced risk of nausea and diarrhea.
  • Reduced risk of new or worsening kidney function.
  • Reduced risk of frequent urination or stinging or burning with urination during treatment, or of chronic urinary problems after treatment.
  • Reduced risk of diarrhea and rectal soreness (proctitis) during treatment and of chronic rectal problems after treatments such as rectal bleeding or ulceration.
  • Reduced radiation to the bone marrow, spleen, and circulating lymphocytes, which may help support the function of the immune system in taking on cancer.
  • Reduced risk of low blood counts (anemia, neutropenia) which may support the body’s tolerance of chemotherapy.
  • Reduced risk of developing a future second tumor or cancer, which is most relevant in younger patients, those with a good prognosis and a long life expectancy, and those patients who may have genetic conditions putting them at higher risk for developing other cancers.

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What to Expect With Proton Therapy

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The first step in your care is a consultation. During consultation, we review your medical history, perform a physical exam, decide if any additional tests are needed, discuss all radiation options that may be appropriate for your treatment plan, make recommendations, and answer questions.

To plan your treatment, you will undergo a “simulation” or planning session. During this visit our radiation therapists will help position you the way you will be treated each day. For patients receiving radiation treatment to the head and neck, a custom plastic mesh mask is made.  This mask helps to get you in the correct position for treatment and fits snugly to remind you to hold still during treatment.  You can see and breathe through the mask.  A CT scan will be done to create a picture of you in the treatment position to design your radiation plan. Some patients also undergo an MRI during this visit to help identify the target for treatment. It normally takes 10 days for the team to design the proton treatment plan and perform the quality assurance checks before treatment begins.

Proton therapy is typically delivered once daily during weekdays, Monday through Friday. Most patients with lymphomas receive three to five weeks of daily radiation. While some conditions are treated with radiation alone, proton therapy may be integrated with chemotherapy, immunotherapy, or other treatments as part of a comprehensive plan of care.

Like other types of radiation, proton therapy treatments are invisible and painless.  Most lymphoma treatments average 30 minutes each day in the treatment room. 

Patients are seen by the radiation oncology physician team weekly during treatment to monitor progress, answer questions, address concerns, and manage any side effects from treatment. Your radiation oncologist will discuss a plan to assess response to treatment and for long-term follow-up after therapy.

Studies on Proton Therapy in Lymphoma

Our team has identified these studies as examples of the clinical benefits of proton therapy in lymphoma.

Patient Stories